GenPlay Multi-Genome
From GenPlay, Einstein Genome Analyzer
Project Introduction
GenPlay Multi-Genome is a project under development that provides a unique platform to analyze personal genome and epigenome information. Because the amount of individual genomes sequenced is expected to increase exponentially in the next few years, we expect this feature of GenPlay to become extremely useful to analyze multiple epigenomes in parallel. Presently, there are no applications that can be used by biologists, post-docs and students to compare human epigenomes in real time. Software such as Vista and D-code are very useful tools that offers the capability to compare the structure of genomes across species, but they do not allow loading of multiple ChIP-Seq tracks or RNA-Seq tracks aligned on different genomes. The meta-genome concept that we have developed is new and powerful. Although all genomes are represented by difference files that are relative to a reference genome, creation of a meta-genome which includes insertion allows for comparison of any two (or more) genomes without any need to use a reference genome.
GenPlay is designed to analyze human genomes, but is perfectly suitable to study any genome provided that the annotation and difference files are available. In fact, some of our most satisfied users are researchers working on small genomes because a smaller genome size allows for truly rapid analysis since GenPlay is built to analyze large mammalian genomes. The programming methods used throughout the proposal as well as the use of Java are not innovative by de-sign. Using well-tried and commonly used programming methods and language will facilitate maintenance and modification of the software.